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持續(xù)長(zhǎng)時(shí)間定量給藥的好幫手

? Alzet Osmotic Pumps 是體積只有膠囊大小的滲透壓泵，可植入實(shí)驗(yàn)動(dòng)物皮下或腹腔內(nèi), 直接或通過(guò)導(dǎo)管以 μl/小時(shí) 的速度持續(xù)準(zhǔn)確地送出測(cè)試藥劑，***長(zhǎng)可達(dá)四個(gè)星期。
? Alzet Osmotic Pumps符合 USP 醫(yī)療用塑膠材料生物相容性標(biāo)準(zhǔn)，適合植入實(shí)驗(yàn)動(dòng)物體內(nèi)，針對(duì)特定部位給藥，或?qū)⑺巹┯脤?dǎo)管導(dǎo)入作用部位, 例如: 脊髓及顱腔內(nèi), 血管內(nèi), 肝臟, 脾臟及其它臟器和創(chuàng)傷處。

Rates & Durations
There are 12 models of ALZET Osmotic Pumps in 3 physical sizes, and a variety of release rates and durations.

ALZET osmotic pumps are miniature, implantable pumps used for research in mice, rats, and other laboratory animals. These infusion pumps continuously deliver drugs, hormones, and other test agents at controlled rates from one day to four weeks without the need for external connections or frequent handling. Their unattended operation eliminates the need for repeated nighttime or weekend dosing.
ALZET pumps can be used for systemic administration when implanted subcutaneously or intraperitoneally. They can be attached to a catheter for intravenous, intracerebral, or intra-arterial infusion. ALZET pumps can also be used for targeted delivery, where the effects of a drug or test agent are localized in a particular tissue or organ, by means of a catheter. The pumps have been used to target delivery to a wide variety of sites including the spinal cord, spleen, liver, organ or tissue transplants, and wound healing sites.
ALZET pumps have been used in thousands of studies on the effects of controlled delivery of a wide range of experimental agents, including peptides, growth factors, cytokines, chemotherapeutic drugs, addictive drugs, hormones, steroids, and antibodies. Due to the unique mechanism by which ALZET pumps operate, compounds of any molecular conformation can be delivered predictably at controlled rates, independent of their physical and chemical properties. A bibliography of pump work which has been documented in the scientific literature is available, as is information on the osmotic delivery mechanism of ALZET pumps.

在全球各地八千項(xiàng)生命科學(xué)實(shí)驗(yàn)研究中, Alzet pumps已成功的運(yùn)送上百種藥劑，包括蛋白質(zhì), 多肽, 生長(zhǎng)因子, 基因研究及治療中的Antisense 和 ***新的干擾RNA ( RNAi), 抗生素, 化療藥, 激素, 類(lèi)固醇及其它短效期的化合物。特別在心血管疾病及神經(jīng)系統(tǒng)疾病的研究中, 通過(guò)ALZET Osmotic pumps持續(xù)給藥可以建立多種疾病的動(dòng)物模型, 如高血壓及Parkinson帕金森病的動(dòng)物模型。